Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of chemotherapy
that is frequently experienced by patients receiving treatment for cancer. CIPN is caused by …

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive,
enduring, and often irreversible adverse effect of many antineoplastic agents, among which …

Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS)
although it is reported by most of these patients. It occurs at all stages of the disease and can …

Spinal cord injury (SCI) is an injury to the spinal cord that leads to varying degrees of motor
and/or sensory deficits and paralysis. Chronic pain of both neuropathic and nociceptive type …

Patients with pelvic pain suffer from psychological conditions at a disproportionately high
rate compared with their peers. We review environmental, genetic, inflammatory, and …

Herpes zoster is a major health burden that can affect individuals of any age. It is seen more
commonly among individuals aged≥ 50 years, those with immunocompromised status, and …

Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

Malignant cells often demonstrate a proliferative advantage when compared to non-
malignant cells. However, the rapid growth and metabolism required for survival can also …

Painful peripheral neuropathy is a common side effect of paclitaxel (PTX). The use of
analgesics is an important component for management of PTX-induced peripheral …