Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …

[HTML][HTML] The role of MicroRNAs in hepatocellular carcinoma

X Xu, Y Tao, L Shan, R Chen, H Jiang, Z Qian… - Journal of …, 2018 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common cancers, leading to the second
cancer-related death in the global. Although the treatment of HCC has greatly improved over …

Aberrant LYZ expression in tumor cells serves as the potential biomarker and target for HCC and promotes tumor progression via csGRP78

Z Gu, L Wang, Q Dong, K Xu, J Ye… - Proceedings of the …, 2023 - National Acad Sciences
Hepatocellular carcinoma (HCC) takes the predominant malignancy of hepatocytes with
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …

Anti-tumoral activity of single and combined regorafenib treatments in preclinical models of liver and gastrointestinal cancers

F Fondevila, C Méndez-Blanco… - … & molecular medicine, 2019 - nature.com
Regorafenib is a sorafenib-derived chemotherapy drug belonging to the multikinase
inhibitor family. This agent effectively targets a wide range of tyrosine kinases involved in …

[HTML][HTML] Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy

Y Sun, W Ma, Y Yang, M He, A Li, L Bai, B Yu… - Asian journal of …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the deadliest cancers due to its complexities,
reoccurrence after surgical resection, metastasis and heterogeneity. In addition to sorafenib …

Doxycycline inducible chimeric antigen receptor T cells targeting CD147 for hepatocellular carcinoma therapy

RY Zhang, D Wei, ZK Liu, YL Yong, W Wei… - Frontiers in Cell and …, 2019 - frontiersin.org
Chimeric antigen receptor T cell (CAR-T) therapy to hematological malignancies has
demonstrated tremendous clinical outcomes. However, the therapeutic efficacy of CAR-T …

TRP channels in digestive tract cancers

P Stokłosa, A Borgström, S Kappel… - International journal of …, 2020 - mdpi.com
Cancers of the digestive tract are among the most prevalent types of cancer. These types of
cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently …

Theranostic micelles based on upconversion nanoparticles for dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

Y Han, Y An, G Jia, X Wang, C He, Y Ding, Q Tang - Nanoscale, 2018 - pubs.rsc.org
Hepatocellular carcinoma (HCC) is frequently metastatic once diagnosed and less likely to
respond to curative surgery, emphasizing the need for the development of more sensitive …

HMGB1 Promotes Resistance to Doxorubicin in Human Hepatocellular Carcinoma Cells by Inducing Autophagy via the AMPK/mTOR Signaling Pathway

J Li, W Zhou, Q Mao, D Gao, L Xiong, X Hu… - Frontiers in …, 2021 - frontiersin.org
Chemoresistance remains as a major hindrance in the treatment of hepatocellular
carcinoma (HCC). High mobility group box protein 1 (HMGB1) enhances autophagic flux …

Adoptive cell transfer therapy for hepatocellular carcinoma

R Zhang, Z Zhang, Z Liu, D Wei, X Wu, H Bian… - Frontiers of …, 2019 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This
malignancy is associated with poor prognosis and high mortality. Novel approaches for …