Programmed cell death (PCD) has been a major area of constantly growing interest over the
last three decades. Originally, apoptosis was considered the only mechanistic pathway for …

Context The use of stereotactic ablative radiotherapy for recurrent and metastatic renal cell
carcinoma (RCC) is not yet standard treatment due to uncertainties regarding its efficacy and …

To date, over 100 small-molecule oncology drugs have been approved by the FDA.
Because of the inherent heterogeneity of tumors, these small molecules are often …

Cisplatin-based chemotherapy often results in the development of chemo-resistance when
used to treat bladder cancer (BC), which is difficult to overcome. Recent data indicate that …

Abstract Brachytherapy (BT), using low-dose-rate (LDR) permanent seed implantation or
high-dose-rate (HDR) temporary source implantation, is an acceptable treatment option for …

Background Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second
leading cause of cancer-related deaths worldwide. As demonstrated in other solid …

Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often
accompanied by severe cardiovascular complications (DCCs) as major causes of death in …

A newly discovered mechanism of cell death, programmed necrosis (necroptosis), combines
features of both necrosis and apoptosis. Necroptosis is tightly modulated by a series of …

Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell
proliferation and induction of cell death. Many research publications discussing the …

Necroptosis, a cell death modality that is defined as a necrosis-like cell death depending on
the receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like …