Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from
this condition have a significantly reduced quality of life. The currently available …

Peripheral tissue injury/inflammation can alter the properties of somatic sensory pathways,
resulting in behavioral hypersensitivity and pathological and/or chronic pain, including …

Peripheral nerve injury activates satellite cells to produce interleukin 1β (IL-1β) which
mediates inflammation and hyperalgesia. This study investigated the hypothesis that …

Previous studies in several different trigeminal nerve injury/inflammation models indicated
that the hyperexcitability of primary afferent neurons contributes to the pain pathway …

Oxytocin (OXT) is a neuropeptide hormone synthesized and secreted by hypothalamic
neurons and has been reported to play a significant role in pain modulation. However, the …

BACKGROUND AND OBJECTIVES: Satellite glial cells in sensory ganglia are a recent
subject of research in the field of pain and a possible therapeutic target in the future …

Background: Glial cells have been shown to directly participate to the genesis and
maintenance of chronic pain in both the sensory ganglia and the central nervous system …

Temporomandibular joint or related masticatory muscle pain represents the most common
chronic orofacial pain condition. Patients frequently report this kind of pain after dental …

Inflammation suppresses satellite glial inward rectifying K+(Kir) currents in the trigeminal
ganglia. Kir channel may be a potential therapeutic target for treatment of pain. ABSTRACT …

The N-methyl-d-aspartate receptor (NMDAR) is a glutamate-gated receptor channel that
plays a role in peripheral neuropathic pain. Src, a protein tyrosine kinase, can regulate the …