This study examined whether local application of a neurokinin‐1 (NK1) receptor antagonist
into the trigeminal ganglia (TRGs) modulates hyperexcitability of trigeminal spinal nucleus …

The mitogen-activated protein kinase, extracellular signal-regulated kinase (ERK), is
activated in experimental models of chronic pain, and is also activated by oestrogen. We …

Background: Temporomandibular disorders (TMDs) are characterized by persistent orofacial
pain and have diverse etiologic factors that are not well understood. It is thought that central …

While physiological pain (nociceptive pain) has a protective role in warning of potential
tissue damage in response to a variety of noxious stimuli, pathological pain (neuropathic …

In the trigeminal system, disruption of acute resolution processing may lead to uncontrolled
inflammation and chronic pain associated with the temporomandibular joint (TMJ). Currently …

In order to clarify the peripheral mechanisms of ectopic persistent pain in a tooth pulp
following pulpal inflammation of an adjacent tooth, masseter muscle activity, phosphorylated …

Temporomandibular disorders represent one of the major challenges in dentistry
therapeutics. This study was undertaken to evaluate the time course of carrageenan …

Background The trigeminal subnuclei interpolaris/caudalis transition zones (Vi/Vc) play an
important role in orofacial deep pain, however, the role of primary afferent projections to the …

The aim of the present study was to investigate the effect of temporomandibular joint
inflammation on the excitability of trigeminal root ganglion neurons innervating the …

In a previous study, we demonstrated that inflammation suppressed inward rectifying K+(Kir)
currents in satellite glial cells (SGCs) from the trigeminal ganglia (TRGs) and that this …