Introduction: Biopharmaceuticals are large protein based drugs which are heterogeneous by
nature due to post translational modifications resulting from cellular production, processing …

Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …

Objectives Macropinocytosis promotes internalization of albumin into cells to serve as a
nutrient supply and is constitutively driven by signaling pathways frequently hyperactivated …

Purpose We performed this meta-analysis to evaluate the prognostic value of maximum of
standardized uptake value (SUV max), metabolic tumor volume (MTV), and total lesion …

Biologicals undergo modifications throughout their commercial lifecycle. Major changes can
unintentionally magnify their inherent physicochemical variability. Although trials comparing …

Purpose The purpose of this study was to assess the efficacy and safety of cetuximab plus
platinum-based chemotherapy for patients specifically diagnosed with recurrent or …

Monoclonal antibodies are important cancer medicines. European Medicines Agency (EMA)
approved 40 and Food and Drug Administration (FDA) 48 anticancer monoclonal antibody …

Background Biosimilars must meet stringent regulatory requirements, both at the time of
authorization and during their lifecycle. Yet it has been suggested that divergence in quality …

Laryngeal squamous cell carcinoma is a common malignancy in men. Bulgaria is one of the
countries in Europe with the highest incidence and mortality rates of the aggressive, severe …

Background Approximately 90% of oral cancers are squamous cell carcinoma (SCC), which
is seen in older men, typically on the lip or lateral part of the tongue. Oral SCC (OSCC) is …