Maintaining consistent quality and clinical performance of biopharmaceuticals
WC Lamanna, J Holzmann, HP Cohen… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Biopharmaceuticals are large protein based drugs which are heterogeneous by
nature due to post translational modifications resulting from cellular production, processing …
nature due to post translational modifications resulting from cellular production, processing …
Shooting at moving and hidden targets—tumour cell plasticity and the notch signalling pathway in head and neck squamous cell carcinomas
J Kałafut, A Czerwonka, A Anameriç… - Cancers, 2021 - mdpi.com
Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …
Nanoparticle albumin-bound paclitaxel with cetuximab and carboplatin as first-line therapy for recurrent or metastatic head and neck cancer: A single-arm, multicenter …
D Adkins, J Ley, O Atiq, S Powell, WC Spanos, M Gitau… - Oral oncology, 2021 - Elsevier
Objectives Macropinocytosis promotes internalization of albumin into cells to serve as a
nutrient supply and is constitutively driven by signaling pathways frequently hyperactivated …
nutrient supply and is constitutively driven by signaling pathways frequently hyperactivated …
Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer: a meta-analysis
L Wang, J Bai, P Duan - Nuclear Medicine Communications, 2019 - journals.lww.com
Purpose We performed this meta-analysis to evaluate the prognostic value of maximum of
standardized uptake value (SUV max), metabolic tumor volume (MTV), and total lesion …
standardized uptake value (SUV max), metabolic tumor volume (MTV), and total lesion …
[HTML][HTML] Extrapolation: experience gained from original biologics
LF Rojas-Chavarro, F de Mora - Drug Discovery Today, 2021 - Elsevier
Biologicals undergo modifications throughout their commercial lifecycle. Major changes can
unintentionally magnify their inherent physicochemical variability. Although trials comparing …
unintentionally magnify their inherent physicochemical variability. Although trials comparing …
[HTML][HTML] Multicenter retrospective study of cetuximab plus platinum-based chemotherapy for recurrent or metastatic oral squamous cell carcinoma
S Yanamoto, M Umeda, M Kioi, T Kirita… - Cancer chemotherapy …, 2018 - Springer
Purpose The purpose of this study was to assess the efficacy and safety of cetuximab plus
platinum-based chemotherapy for patients specifically diagnosed with recurrent or …
platinum-based chemotherapy for patients specifically diagnosed with recurrent or …
Monoclonal Antibody Biosimilars for Cancer Treatment
LN Broer, DG Knapen, DJA de Groot, PGM Mol… - iScience, 2024 - cell.com
Monoclonal antibodies are important cancer medicines. European Medicines Agency (EMA)
approved 40 and Food and Drug Administration (FDA) 48 anticancer monoclonal antibody …
approved 40 and Food and Drug Administration (FDA) 48 anticancer monoclonal antibody …
Batch-to-batch consistency of SB4 and SB2, etanercept and infliximab biosimilars
HC Ebbers, B Fehrmann, M Ottosen, N Hvorslev… - BioDrugs, 2020 - Springer
Background Biosimilars must meet stringent regulatory requirements, both at the time of
authorization and during their lifecycle. Yet it has been suggested that divergence in quality …
authorization and during their lifecycle. Yet it has been suggested that divergence in quality …
[PDF][PDF] The role of miRNAs and lncRNAs in laryngeal squamous cell carcinoma-a mini-review
Laryngeal squamous cell carcinoma is a common malignancy in men. Bulgaria is one of the
countries in Europe with the highest incidence and mortality rates of the aggressive, severe …
countries in Europe with the highest incidence and mortality rates of the aggressive, severe …
[PDF][PDF] Cancers of the oral mucosa
C Scully - Medscape. np Web, 2016 - centrodontoiatriconocerino.it
Background Approximately 90% of oral cancers are squamous cell carcinoma (SCC), which
is seen in older men, typically on the lip or lateral part of the tongue. Oral SCC (OSCC) is …
is seen in older men, typically on the lip or lateral part of the tongue. Oral SCC (OSCC) is …