[HTML][HTML] Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology

Z Bradley, N Bhalla - Biosensors and Bioelectronics, 2023 - Elsevier
Sepsis is a life-threatening immune response which is caused by a wide variety of sources
and is a leading cause of mortality globally. Rapid diagnosis and appropriate antibiotic …

Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis

K Kharga, L Kumar, SKS Patel - Biomedicines, 2023 - mdpi.com
Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …

Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis

I Joshi, WP Carney, EP Rock - Frontiers in immunology, 2023 - frontiersin.org
Sepsis, a heterogeneous clinical syndrome, features a systemic inflammatory response to
tissue injury or infection, followed by a state of reduced immune responsiveness …

Vasopressin and its analogues: from natural hormones to multitasking peptides

M Glavaš, A Gitlin-Domagalska, D Dębowski… - International journal of …, 2022 - mdpi.com
Human neurohormone vasopressin (AVP) is synthesized in overlapping regions in the
hypothalamus. It is mainly known for its vasoconstricting abilities, and it is responsible for the …

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

In situ neutralization and detoxification of LPS to attenuate hyperinflammation

X Li, S Qu, X Song, C Wu, J Shen, K Zhu - Advanced Science, 2023 - Wiley Online Library
Hyperinflammation elicited by lipopolysaccharide (LPS) that derives from multidrug‐resistant
Gram‐negative pathogens, leads to a sharp increase in mortality globally. However …

[HTML][HTML] Roles of ginsenosides in sepsis

T Yu, Y Tang, F Zhang, L Zhang - Journal of Ginseng Research, 2023 - Elsevier
The herbal medication Panax ginseng Meyer has widespread use in China, Korea, and
other parts of the world. The main constituents of ginseng are ginsenosides, which include …

The techniques of blood purification in the treatment of sepsis and other hyperinflammatory conditions

G Berlot, A Tomasini, S Zanchi, E Moro - Journal of Clinical Medicine, 2023 - mdpi.com
Even in the absence of strong indications deriving from clinical studies, the removal of
mediators is increasingly used in septic shock and in other clinical conditions characterized …

The prognostic accuracy evaluation of mNUTRIC, APACHE II, SOFA, and SAPS 2 scores for mortality prediction in patients with sepsis

PD Hai, LT Viet Hoa - Critical Care Research and Practice, 2022 - Wiley Online Library
Background. The modified Nutrition Risk in the Critically Ill (mNUTRIC) score is a helpful tool
to evaluate nutritional risk in critically ill patients. However, there is a lack of data on the …

Hemoperfusion and immunomodulation

C Ronco, S Samoni, R Bellomo - Contributions to …, 2023 - pubmed.ncbi.nlm.nih.gov
Recent development in sorbent technology has spurred new interest in the potential of
hemoperfusion (HP) in clinical conditions such as cytokine release syndromes and sepsis …