Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

Pulmonary hypertension (PH) is a frequent complication of interstitial lung disease (ILD).
Although PH has mostly been described in idiopathic pulmonary fibrosis, it can manifest in …

Rationale: Cor pulmonale (right ventricular [RV] dilation) and cor pulmonale parvus (RV
shrinkage) are both described in chronic obstructive pulmonary disease (COPD). The …

Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by recurrent or
unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial …

Stiffening of the pulmonary arterial bed with the subsequent increased load on the right
ventricle is a paramount feature of pulmonary hypertension (PH). The pathophysiology of …

Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have morphologic
changes to the pulmonary vasculature. These include pruning of the distal vessels, dilation …

Background Chest computed tomography (CT) is a widely used method to assess
morphological and dynamic abnormalities in chronic obstructive pulmonary disease …

COPD is the second most common cause of pulmonary hypertension, and is a common
complication of severe COPD with significant implications for both quality of life and …

There is an increased appreciation for the importance of the right heart and pulmonary
circulation in several disease states across the spectrum of pulmonary hypertension and left …

Rationale Severe pulmonary hypertension (PH) is very uncommon in COPD, and a distinct
phenotype has been hypothesised. We aimed to evaluate whether CT can help to recognise …