Lifetime relapse rates remain a major obstacle in addressing the current opioid crisis.
Relapse to opioid use can be modeled in rodent studies where drug self-administration is …

Opioid addiction and overdose are at record levels in the United States. This is driven, in
part, by their widespread prescription for the treatment of pain, which also increased …

Abstract Background The National Institute on Drug Abuse (NIDA) recently released a
Request for Information (RFI) soliciting comments on nonhuman animal models of …

Rationale Animal models of compulsive drug use that continues despite negative
consequences can be used to investigate the neural mechanisms of addiction. However …

Addiction to drug and alcohol is regarded as a major health problem worldwide for which
available treatments show limited effectiveness. The biggest challenge remains to enhance …

Boredom is an emotional state that occurs when an individual has nothing to do, is not
interested in the surrounding, and feels dreary and in a monotony. While this condition is …

Here we provide evidence that both pharmacological and environmental manipulations
similarly blunt the cortisol release in response to an acute stressor in adult zebrafish …

Environmental factors profoundly affect the addictive potential of drugs of abuse and may
also modulate the neuro-anatomical/neuro-chemical impacts of uncontrolled drug use and …

Two of the primary features of Parkinson's disease (PD) are the accumulation of α-synuclein
(α-Syn) and the depletion of lysosomal-associated membrane protein 1 (LAMP1) in the …

Background Treatment strategies that aim to promote abstinence to heroin use and reduce
vulnerability to drug-use resumption are limited in sustainability and long-term efficacy. We …