Skeletal muscle has an extraordinary regenerative capacity due to the activity of tissue-
specific muscle stem cells. Consequently, these cells have received the most attention in …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

The generation of functional skeletal muscle tissues from human pluripotent stem cells
(hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) …

Generating human skeletal muscle models is instrumental for investigating muscle
pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial …

The CRISPR/Cas9 genome-editing platform is a promising technology to correct the genetic
basis of hereditary diseases. The versatility, efficiency and multiplexing capabilities of the …

Following their discovery in 1961, it was speculated that satellite cells were dormant
myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Transmission of external stimuli to intracellular effector proteins via signalling …

Adult muscle stem cells, or satellite cells have essential roles in homeostasis and
regeneration of skeletal muscles. Satellite cells are located within a niche that includes …

Distinct cell populations with regenerative capacity have been reported to contribute to
myofibres after skeletal muscle injury, including non-satellite cells as well as myogenic …