Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …

Migraine is a common neurological disorder with a diverse clinical phenotype that
comprises more than just head pain. Premonitory (prodromal) symptoms can start hours to …

Cholangiocytes are epithelial cells that line the intra-and extrahepatic ducts of the biliary
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …

Somatostatin analogs (SA) are widely used in acromegaly, either as first-line or adjuvant
treatment after surgery. First-line treatment with these drugs is generally used in the patients …

The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-
NETs) have increased in the past 20 years. GEP-NETs are heterogeneous tumors, in terms …

Background & Aims: In polycystic liver diseases (PCLDs), increased cholangiocyte
proliferation and fluid secretion are key features and cholangiocyte adenosine 3′, 5 …

Migraine is a common disabling neurovascular primary headache disorder. The
pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The …

Objective It is believed that the variable effectiveness of somatostatin analogs in post-
surgical management of somatotropinomas and non-functioning pituitary adenomas (NFPA) …

The heterotrimeric G-protein-coupled receptors (GPCR) represent the largest and most
diverse family of cell surface receptors and proteins. GPCR are widely distributed in the …