Peptide-drug conjugates and their targets in advanced cancer therapies
P Hoppenz, S Els-Heindl, AG Beck-Sickinger - Frontiers in chemistry, 2020 - frontiersin.org
Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …
standard treatments achieve significant effects in growth inhibition and tumor elimination …
International Union of Basic and Clinical Pharmacology. CV. Somatostatin receptors: structure, function, ligands, and new nomenclature
T Günther, G Tulipano, P Dournaud, C Bousquet… - Pharmacological …, 2018 - ASPET
Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …
Biological insights from the premonitory symptoms of migraine
N Karsan, PJ Goadsby - Nature Reviews Neurology, 2018 - nature.com
Migraine is a common neurological disorder with a diverse clinical phenotype that
comprises more than just head pain. Premonitory (prodromal) symptoms can start hours to …
comprises more than just head pain. Premonitory (prodromal) symptoms can start hours to …
[HTML][HTML] Physiology of cholangiocytes
JH Tabibian, AI Masyuk, TV Masyuk… - Comprehensive …, 2013 - ncbi.nlm.nih.gov
Cholangiocytes are epithelial cells that line the intra-and extrahepatic ducts of the biliary
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …
Resistance to somatostatin analogs in acromegaly
A Colao, RS Auriemma, G Lombardi… - Endocrine …, 2011 - academic.oup.com
Somatostatin analogs (SA) are widely used in acromegaly, either as first-line or adjuvant
treatment after surgery. First-line treatment with these drugs is generally used in the patients …
treatment after surgery. First-line treatment with these drugs is generally used in the patients …
Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy
KE Öberg, JC Reubi, DJ Kwekkeboom, EP Krenning - Gastroenterology, 2010 - Elsevier
The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-
NETs) have increased in the past 20 years. GEP-NETs are heterogeneous tumors, in terms …
NETs) have increased in the past 20 years. GEP-NETs are heterogeneous tumors, in terms …
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3′, 5′-cyclic monophosphate
TV Masyuk, AI Masyuk, VE Torres, PC Harris… - Gastroenterology, 2007 - Elsevier
Background & Aims: In polycystic liver diseases (PCLDs), increased cholangiocyte
proliferation and fluid secretion are key features and cholangiocyte adenosine 3′, 5 …
proliferation and fluid secretion are key features and cholangiocyte adenosine 3′, 5 …
Migraine and neuropeptides
J Tajti, D Szok, Z Majláth, B Tuka, A Csáti, L Vécsei - Neuropeptides, 2015 - Elsevier
Migraine is a common disabling neurovascular primary headache disorder. The
pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The …
pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The …
Quantitative analysis of somatostatin receptor subtype (SSTR1–5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas
GF Taboada, RM Luque, W Bastos… - European Journal of …, 2007 - academic.oup.com
Objective It is believed that the variable effectiveness of somatostatin analogs in post-
surgical management of somatotropinomas and non-functioning pituitary adenomas (NFPA) …
surgical management of somatotropinomas and non-functioning pituitary adenomas (NFPA) …
Modulation of pain transmission by G-protein-coupled receptors
The heterotrimeric G-protein-coupled receptors (GPCR) represent the largest and most
diverse family of cell surface receptors and proteins. GPCR are widely distributed in the …
diverse family of cell surface receptors and proteins. GPCR are widely distributed in the …