Scientific and clinical progress together with the development of effective novel therapeutic
options has engendered multiple important changes in the diagnosis and management of …

Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and
effective therapy are critical. This revision and update of the global WAO/EAACI guideline on …

Perioperative hypersensitivity reactions (POH) constitute a clinical and diagnostic challenge,
a consequence of heterogeneous clinical presentations, and multiple underlying …

Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation
proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation …

To date the pathophysiology of COVID-19 remains unclear: this represents a factor
determining the current lack of effective treatments. In this paper, we hypothesized a …

Angioedema (AE) occurring during ACE inhibitor therapy (ACEi-AE) is a rare complication
involving between 0.1 and 0.7% of treated patients. AE can also complicate other …

This is a case of a patient who presented with an urticarial rash 48 hours before developing
symptoms of fever and a continuous cough. She subsequently developed angioedema of …

Hereditary angioedema (HAE) is becoming much more genetically complex than was
initially considered. Thus, the role of HAE genetics is expanding beyond research …

The evolution in the knowledge of rare genetic diseases such as hereditary angioedema
(HAE) has increased at a parallel pace with the development of new molecular tools. The …

Chronic spontaneous urticaria (CSU) is primarily a T2-dominant disease with a complex
genetic background. Skin mast cell activation can be induced not only via the IgE-FcεRI axis …