Background: The connection between uric acid (UA) and renal impairment is well known
due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging …

This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Homeostasis is a prerequisite for health. When homeostasis becomes disrupted, dysfunction
occurs. This is especially the case for the gut microbiota, which under normal conditions …

Background With the change of dietary habits and lifestyles, people tend to have elevated
blood uric acid levels at a younger age, and this can cause serious health problems, such as …

Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the
development of hypertension and chronic kidney disease. A 2-hit model has been proposed …

Uraemic syndrome (also known as uremic syndrome) in patients with advanced chronic
kidney disease involves the accumulation in plasma of small-molecule uraemic solutes and …

Disorders of uric acid metabolism may be associated with pathological processes in many
diseases, including diabetes mellitus, cardiovascular disease, and kidney disease. These …

The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …

Urate homeostasis in humans is a complex and highly heritable process that involves ie,
metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate …

Probenecid is used to treat gout and hyperuricemia as well as increase plasma levels of
antiviral drugs and antibiotics. In vivo, probenecid mainly inhibits the renal SLC22 organic …