Endoplasmic reticulum-plasma membrane contact sites (ER-PM MCS) are a specialised
domain involved in the control of Ca 2+ dynamics and various Ca 2+-dependent cellular …

Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but
often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid …

Phosphoinositides are low-abundant lipid signaling molecules that govern key cellular
processes including membrane trafficking, cytoskeletal rearrangement, and cell signaling to …

Munc13-1 is essential for vesicle docking and fusion at the active zone of synapses. Here,
we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich …

ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating
cell signalling pathways and, as such, have become therapeutic targets for diseases such as …

ABSTRACT The phospholipid phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P2] acts as
a signaling lipid at the plasma membrane (PM) with pleiotropic regulatory actions on …

Abstract Background The Hippo pathway plays a critical role in controlled cell proliferation.
The tumor suppressor Merlin and large tumor suppressor kinase 1 (LATS1) mediate …

Oxysterol-binding protein (OSBP)-related proteins (ORPs) 5 and 8 have been shown to
deplete the lipid phosphatidylinositol 4-phosphate (PI4P) at sites of membrane contact …

The lipid phosphatidylinositol 4-phosphate (PI4P) plays a master regulatory role at Golgi
membranes, orchestrating membrane budding, non-vesicular lipid transport and membrane …