Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
[HTML][HTML] Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII
JB Rodríguez-Molina, S West, LA Passmore - Molecular cell, 2023 - cell.com
Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …
and steady expression of some proteins as well as the rapidly changing production of other …
R loops: new modulators of genome dynamics and function
JM Santos-Pereira, A Aguilera - Nature Reviews Genetics, 2015 - nature.com
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
[HTML][HTML] Transcription-coupled nucleotide excision repair and the transcriptional response to UV-induced DNA damage
N Nieto Moreno, AM Olthof… - Annual review of …, 2023 - annualreviews.org
Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …
Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
NJ Proudfoot - Science, 2016 - science.org
BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
Transcription termination and the control of the transcriptome: why, where and how to stop
O Porrua, D Libri - Nature reviews Molecular cell biology, 2015 - nature.com
Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …
thus delimitating transcription units; however, the functional importance of termination …
[HTML][HTML] Small nucleolar RNAs tell a different tale
J Kufel, P Grzechnik - Trends in Genetics, 2019 - cell.com
Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …
[HTML][HTML] Effects of transcription elongation rate and Xrn2 exonuclease activity on RNA polymerase II termination suggest widespread kinetic competition
The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …
[HTML][HTML] Dealing with pervasive transcription
TH Jensen, A Jacquier, D Libri - Molecular cell, 2013 - cell.com
Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly
found RNAs have functions and how many are byproducts of functional, or spurious …
found RNAs have functions and how many are byproducts of functional, or spurious …
Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
Z Hasanova, V Klapstova, O Porrua, R Stefl… - Nucleic Acids …, 2023 - academic.oup.com
Prolonged pausing of the transcription machinery may lead to the formation of three-
stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the …
stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the …