Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many
functions, regulating a diversity of processes: from cell movement during embryogenesis to …

The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide
range of internal and external cellular stress signals. Beside the stress response, the JNK …

Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and
molecular mechanisms driving the invasive growth patterns and therapeutic resistance are …

JNK is named after c-Jun N-terminal kinase, as it is responsible for phosphorylating c-Jun.
As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as …

Glioblastoma multiforme (GBM) is an aggressive brain cancer showing poor prognosis.
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …

Despite advances in the treatment of solid tumors, the prognosis of patients with many
cancers remains poor, particularly of those with primary and metastatic brain tumors. In the …

The final size and function of the adult central nervous system (CNS) are determined by
neuronal lineages generated by neural stem cells (NSCs) in the developing brain. In …

Glioblastomas (GBMs) are tumors that have a high ability to migrate, invade and proliferate
in the healthy tissue, what greatly impairs their treatment. These characteristics are …

An increasing body of evidence has become available to reveal the synaptic and functional
integration of glioma into the brain network, facilitating tumor progression. The novel …