Even before the publication of Darwin's Origin of Species, the perception of evolutionary
change has been a tree-like pattern of diversification-with divergent branches spreading …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a
unique redox metabolism which is based on trypanothione. The bis (glutathionyl) …

Background Photosynthetic euglenids are major contributors to fresh water ecosystems.
Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability to thrive in …

Trypanosoma brucei evades the adaptive immune response through the expression of
antigenically distinct Variant Surface Glycoprotein (VSG) coats. To understand the …

Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is
Macaca fascicularis (the 'kra'monkey); however, it is now increasingly recognized as a …

Some development stages of the trypanosomatid protozoan parasites are well adapted to in
vitro culture. They can be maintained in rich medium containing large excess of glucose and …

The kinetochore is the macromolecular protein complex that directs chromosome
segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of …

Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

Transcription of protein-coding genes in trypanosomes is polycistronic and gene expression
is primarily regulated by post-transcriptional mechanisms. Sequence motifs in the …