The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …

The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

Simple Summary Chemotherapy is a key modality in today's practice of clinical oncology.
The potential for systemic treatment of cancer patients with cytotoxic agents was discovered …

For successful translation of targeting nanomedicines from bench to bedside, it is vital to
address their most common drawbacks namely rapid clearance and off-target accumulation …

Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute
one of the main reasons of deaths worldwide. The side effects of chemotherapy and drug …

Cancer is the second leading cause of death affecting nearly one in two people, and the
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …

Therapeutic peptides are attracting increasing attention for biomedical applications.
Peptides present promising opportunities in targeted drug delivery due to their high …

Intrinsic anticancer drug resistance appearing prior to chemotherapy as well as acquired
resistance due to drug treatment, remain the dominant impediments towards curative cancer …

Abstract Background Peptide-drug-conjugates (PDCs) are being developed as an effective
strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges …