Abstract The phosphoinositide 3-kinase (PI3K) signaling pathway is well-known for its
important role in cancer growth, proliferation and migration. The activation of PI3K pathway …

This study aimed to explore the efficacy and potential mechanisms of rechallenge therapy
with microtubule-targeting agents (MTAs) in patients with HER2-low metastatic breast …

Abstract Phosphoinositide 3-kinase (PI3K)-α represents a key intracellular signal transducer
involved in the regulation of key cell functions such as cell survival and proliferation …

Disulfidptosis is a novel cell death mode in which the accumulation of disulfide bonds in
tumor cells leads to cell disintegration and death. Long-stranded noncoding RNAs …

Alpelisib (ALP) is a potent anti-cancer drug showing promising activity against advanced
breast cancers. Hence, profound understanding of its binding dynamics within the …

Introduction Primary liver cancer is a major health problem being the sixth most frequent
cancer in the world and the fourth most frequent cause of cancer-related death in the world …

Rhabdomyosarcoma (RMS) is a highly malignant and metastatic pediatric cancer arising
from skeletal muscle myogenic progenitors. Recent studies have shown an important role for …

Cancer is the leading cause of death worldwide for which effective treatments remain
limited. This article aimed to critically review and discuss the potential of targeting cell cycle …

Simple Summary Despite recent dramatic progress, developing drugs that target oncogenic
KRAS or its key effectors remains a major challenge for cancer research. Improving our …

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-
associated protein 9 (Cas9) system is a powerful gene editing tool originated from …