[HTML][HTML] Regulatory roles of histone modifications in filamentous fungal pathogens

Y Lai, L Wang, W Zheng, S Wang - Journal of Fungi, 2022 - mdpi.com
Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts
including plants and insects. The dynamic infection process requires rapid and fine-tuning …

[HTML][HTML] Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans

ST Denham, JCS Brown - Journal of Fungi, 2018 - mdpi.com
Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

[HTML][HTML] Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age

S Bhattacharya, T Holowka, EP Orner, BC Fries - Scientific reports, 2019 - nature.com
Candida auris is an emerging multi-drug resistant yeast that causes systemic infections.
Here we show that C. auris undergoes replicative aging (RA) that results from asymmetric …

[HTML][HTML] HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence

F Brandão, SK Esher, KS Ost, K Pianalto, CB Nichols… - Scientific reports, 2018 - nature.com
The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic
changes to promote its survival in specific ecological niches and inside the host. To explore …

[PDF][PDF] The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans

MA Munshi, JM Gardin, A Singh, C Luberto, R Rieger… - Cell reports, 2018 - cell.com
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases
every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans …

[HTML][HTML] Systematic characterization of Ustilago maydis sirtuins shows Sir2 as a modulator of pathogenic gene expression

B Navarrete, JI Ibeas, RR Barrales - Frontiers in Microbiology, 2023 - frontiersin.org
Phytopathogenic fungi must adapt to the different environmental conditions found during
infection and avoid the immune response of the plant. For these adaptations, fungi must …

Sirtuins in epigenetic silencing and control of gene expression in model and pathogenic fungi

G Zhao, LN Rusche - Annual Review of Microbiology, 2022 - annualreviews.org
Fungi, including yeasts, molds, and mushrooms, proliferate on decaying matter and then
adopt quiescent forms once nutrients are depleted. This review explores how fungi use …

A fungal sirtuin modulates development and virulence in the insect pathogen, Beauveria bassiana

Q Cai, L Tian, JT Xie, QY Huang… - Environmental …, 2021 - Wiley Online Library
Chromatin transitions are mediated in part by acetylation/deacetylation post‐translational
modifications of histones. Histone deacetylases, eg sirtuins (Sir‐proteins), repress …

[HTML][HTML] Replicative aging in pathogenic fungi

S Bhattacharya, T Bouklas, BC Fries - Journal of Fungi, 2020 - mdpi.com
Candida albicans, Candida auris, Candida glabrata, and Cryptococcus neoformans are
pathogenic yeasts which can cause systemic infections in immune-compromised as well as …

[HTML][HTML] Generational distribution of a Candida glabrata population: Resilient old cells prevail, while younger cells dominate in the vulnerable host

T Bouklas, L Alonso-Crisóstomo, T Székely Jr… - PLoS …, 2017 - journals.plos.org
Similar to other yeasts, the human pathogen Candida glabrata ages when it undergoes
asymmetric, finite cell divisions, which determines its replicative lifespan. We sought to …