Age is an important risk for autoimmunity, and many autoimmune diseases preferentially
occur in the second half of adulthood when immune competence has declined and thymic T …

Immune aging is a complex process rendering the host susceptible to cancer, infection, and
insufficient tissue repair. Many autoimmune diseases preferentially occur during the second …

Immune aging is best known for its immune defects that increase susceptibility to infections
and reduce adaptive immune responses to vaccination. In parallel, the aged immune system …

Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system where
evidence implicates an aberrant adaptive immune response in the accrual of neurological …

Growing experience with engineered chimeric antigen receptor (CAR)‐T cells has revealed
some of the challenges associated with developing patient‐specific therapy. The promising …

Accumulating evidence from murine and human studies supports a key role for interleukin‐
17 (IL‐17) and IL‐21 in the pathogenesis of inflammatory arthritis. The pathways and …

Cord blood is currently used as an alternative to bone marrow as a source of stem cells for
hematopoietic reconstitution after ablation. It is also under intense preclinical investigation …

Ex vivo expanded CD4+ CD25highCD127-T regulatory cells (Tregs) are recognized as a
promising candidate for immunosuppressive therapy in humans. However, due to the …

Switching the balance from rejection of major histocompatibility-mismatched grafts toward
long-term tolerance of donor grafts, with the need for minimal immunosuppressive drugs, is …

T-cell depletion therapy is used to prevent acute allograft rejection, treat autoimmunity and
create space for bone marrow or hematopoietic cell transplantation. The evolved response …