Background Oxidative stress, defined as an imbalance between pro-oxidants and
neutralizing antioxidants within the body, is a growing public health concern. Oxidative …

Oral melatonin is a potential alternative treatment for hypertension and nocturnal
hypertension. However, high‐quality and relevant meta‐analyses are lacking. This meta …

Among cardiovascular diseases, hypertension is one of the main risk factors predisposing to
fatal complications. Oxidative stress and chronic inflammation have been identified as …

Starting from the macro-category “sleep-wake disorders”, as defined in DSM-V, the
individual pathological conditions were defined, focusing on the contextual and clinical …

Endothelial dysfunction (ED) is a crucial and initial stage for the development of
cardiovascular diseases. Accumulated evidence has demonstrated causative links between …

Melatonin is a hormonal product of the pineal gland, a fact that is often forgotten. Instead it is
promoted as a dietary supplement that will overcome insomnia, as an antioxidant and as a …

Background Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension
are two complications that may develop in diabetic patients if hyperglycemia, insulin …

Purpose Clinical trials considering the effects of artichoke supplementation on blood
pressure have yielded different and contradictory outcomes. Thus, a systematic review and …

Objectives Studies suggest that melatonin may promote cardiovascular protection. Previous
trials have primarily been performed on co-morbid patients. Little information exist on the …

Purpose Intrafollicular fluid (IFF) melatonin plays a decisive role in maintaining granulosa
cells' DNA integrity and protects them against apoptosis. It reduces oxidative stress and …