Exploring the structural dynamics of the vesicle priming machinery

D An, M Lindau - Biochemical Society Transactions, 2024 - portlandpress.com
Various cell types release neurotransmitters, hormones and many other compounds that are
stored in secretory vesicles by exocytosis via the formation of a fusion pore traversing the …

Different states of synaptic vesicle priming explain target cell type–dependent differences in neurotransmitter release

M Aldahabi, E Neher, Z Nusser - Proceedings of the …, 2024 - National Acad Sciences
Pronounced differences in neurotransmitter release from a given presynaptic neuron,
depending on the synaptic target, are among the most intriguing features of cortical …

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

FJ López-Murcia, KH Lin, MMM Berns… - Proceedings of the …, 2024 - National Acad Sciences
The presynaptic SNARE-complex regulator complexin (Cplx) enhances the fusogenicity of
primed synaptic vesicles (SVs). Consequently, Cplx deletion impairs action potential-evoked …

A Reduction in the Readily Releasable Vesicle Pool Impairs GABAergic Inhibition in the Hippocampus after Blood–Brain Barrier Dysfunction

K Lippmann - International Journal of Molecular Sciences, 2024 - mdpi.com
Major burdens for patients suffering from stroke are cognitive co-morbidities and
epileptogenesis. Neural network disinhibition and deficient inhibitive pulses for fast network …

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

K Reim, FJ López Murcia, KH Lin… - Proceedings of the …, 2024 - diposit.ub.edu
The presynaptic SNARE-complex regulator complexin (Cplx) enhances the fusogenicity of
primed synaptic vesicles (SVs). Consequently, Cplx deletion impairs action potential-evoked …