Clinical use of molecular data in thyroid nodules and cancer

AS Alzahrani - The Journal of Clinical Endocrinology & …, 2023 - academic.oup.com
Over the past 3 decades, advances in the molecular genetics of thyroid cancer (TC) have
been translated into diagnostic tests, prognostic markers, and therapeutic agents. The main …

Genomic and transcriptomic characteristics of metastatic thyroid cancers with exceptional responses to radioactive iodine therapy

L Boucai, M Saqcena, F Kuo, RK Grewal, N Socci… - Clinical Cancer …, 2023 - AACR
Purpose: The determinants of response or resistance to radioiodine (RAI) are unknown. We
aimed to identify genomic and transcriptomic factors associated with structural responses to …

Clinical Implications of mTOR Expression in Papillary Thyroid Cancer—A Systematic Review

A Derwich, M Sykutera, B Bromińska, M Andrusiewicz… - Cancers, 2023 - mdpi.com
Simple Summary Papillary thyroid cancer (PTC) comprises approximately 80% of all thyroid
malignancies. The field of PTC genetics and cancerogenesis remains undetermined …

Disease-specific survival trends for patients presenting with differentiated thyroid cancer and distant metastases in the United States, 1992–2018

A Wilhelm, PC Conroy, L Calthorpe, AM Shui… - Thyroid, 2023 - liebertpub.com
Objective: Differentiated thyroid cancer (DTC) is associated with an excellent prognosis, but
patients with distant metastatic DTC have a 10-year disease-specific survival (DSS) of just …

Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice

K Kakudo - Cancers, 2022 - mdpi.com
Simple Summary Histopathological diagnosis is prone to significant observer variation in the
diagnosis of papillary thyroid carcinomas (PTCs) due to different thresholds of malignancy …

Molecular signature incorporating the immune microenvironment enhances thyroid cancer outcome prediction

GJ Xu, MA Loberg, JN Gallant, Q Sheng, SC Chen… - Cell Genomics, 2023 - cell.com
Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet,
thyroid cancer management is largely guided by staging and histology, with few molecular …

A Critical Assessment of Diagnostic Criteria for the Tall Cell Subtype of Papillary Thyroid Carcinoma—How Much? How Tall? And When Is It Relevant?

J Turchini, TL Fuchs, A Chou, L Sioson, A Clarkson… - Endocrine …, 2023 - Springer
Tall cell papillary thyroid carcinoma (TC-PTC) is considered adverse histology. However,
previous studies are confounded by inconsistent criteria and strong associations with other …

Papillary thyroid carcinomas with tall cell features: an intermediate entity between classic and tall cell subtypes

A Bikas, K Wong, T Pappa, S Ahmadi, CB Wakefield… - Thyroid, 2023 - liebertpub.com
Background: While the diagnosis of papillary thyroid carcinomas (PTCs) with tall cell
features (PTCtcf) is often made for carcinomas with histological features intermediate …

Mutation in Genes Encoding Key Functional Groups Additively Increase Mortality in Patients with BRAFV600E-Mutant Advanced Papillary Thyroid Carcinoma

E Song, M Jin, A Jang, MJ Jeon, DE Song, HJ Yoo… - Cancers, 2021 - mdpi.com
Simple Summary The BRAFV600E point mutation is the most common driver mutation in
papillary thyroid carcinoma (PTC) and is known to be associated with aggressive clinical …

LncRNA ABHD11-AS1 promotes tumor progression in papillary thyroid carcinoma by regulating EPS15L1/EGFR signaling pathway

H Lu, C Zhu, Y Chen, Y Ruan, L Fan, Q Chen… - Clinical and Translational …, 2022 - Springer
Abstract Objectives lncRNA ABHD11 antisense RNA 1 (ABHD11-AS1) acts as an oncogene
involved in papillary thyroid carcinoma (PTC) occurrence and progression. ABHD11-AS1 …