Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Simple Summary Cancer metastasis is often associated with a dismal prognosis for the
patient. It is, therefore, crucial to understand the mechanisms behind the cascade of events …

Cancer-associated fibroblasts (CAFs) were originally presumed to represent a
homogeneous population uniformly driving tumorigenesis, united by their morphology and …

Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur
and develop therapy resistance. During treatment, the tissue surrounding tumors is also …

Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in
adults and is highly metastatic, resulting in a poor patient prognosis. Sphingolipid …

Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …

The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug
discovery. This protease activates the Spike protein of severe acute respiratory syndrome …

Luteolin is a flavonoid widely present in various traditional Chinese medicines. In recent
years, luteolin has received more attention due to its impressive liver protective effect, such …

The treatment landscape for metastatic renal cell carcinoma (mRCC) and urothelial
carcinoma (mUC) has evolved rapidly in recent years with the approval of several …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide,
with high rates of recurrence and death. Surgical resection and ablation therapy have limited …