[HTML][HTML] The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies
R Bai, Y Li, L Jian, Y Yang, L Zhao, M Wei - Molecular Cancer, 2022 - Springer
Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …
[HTML][HTML] The role of cancer-associated fibroblasts in cancer invasion and metastasis
PJ Asif, C Longobardi, M Hahne, JP Medema - Cancers, 2021 - mdpi.com
Simple Summary Cancer metastasis is often associated with a dismal prognosis for the
patient. It is, therefore, crucial to understand the mechanisms behind the cascade of events …
patient. It is, therefore, crucial to understand the mechanisms behind the cascade of events …
[HTML][HTML] Cancer-associated fibroblasts—heroes or villains?
Cancer-associated fibroblasts (CAFs) were originally presumed to represent a
homogeneous population uniformly driving tumorigenesis, united by their morphology and …
homogeneous population uniformly driving tumorigenesis, united by their morphology and …
Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence
E Fletcher-Sananikone, S Kanji, N Tomimatsu… - Cancer research, 2021 - AACR
Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur
and develop therapy resistance. During treatment, the tissue surrounding tumors is also …
and develop therapy resistance. During treatment, the tissue surrounding tumors is also …
[HTML][HTML] Machine learning to construct sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with uveal …
H Chi, G Peng, J Yang, J Zhang, G Song… - Frontiers in …, 2022 - frontiersin.org
Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in
adults and is highly metastatic, resulting in a poor patient prognosis. Sphingolipid …
adults and is highly metastatic, resulting in a poor patient prognosis. Sphingolipid …
[HTML][HTML] Role of cytokines and chemokines in angiogenesis in a tumor context
M Geindreau, M Bruchard, F Vegran - Cancers, 2022 - mdpi.com
Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …
supply, provided by blood vessels created by angiogenesis. Numerous studies have …
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
M Mahoney, VC Damalanka… - Proceedings of the …, 2021 - National Acad Sciences
The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug
discovery. This protease activates the Spike protein of severe acute respiratory syndrome …
discovery. This protease activates the Spike protein of severe acute respiratory syndrome …
[HTML][HTML] Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
C Yao, S Dai, C Wang, K Fu, R Wu, X Zhao… - Biomedicine & …, 2023 - Elsevier
Luteolin is a flavonoid widely present in various traditional Chinese medicines. In recent
years, luteolin has received more attention due to its impressive liver protective effect, such …
years, luteolin has received more attention due to its impressive liver protective effect, such …
Cabozantinib in combination with immunotherapy for advanced renal cell carcinoma and urothelial carcinoma: rationale and clinical evidence
P Bergerot, P Lamb, E Wang, SK Pal - Molecular cancer therapeutics, 2019 - AACR
The treatment landscape for metastatic renal cell carcinoma (mRCC) and urothelial
carcinoma (mUC) has evolved rapidly in recent years with the approval of several …
carcinoma (mUC) has evolved rapidly in recent years with the approval of several …
[HTML][HTML] Drug delivery strategy in hepatocellular carcinoma therapy
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide,
with high rates of recurrence and death. Surgical resection and ablation therapy have limited …
with high rates of recurrence and death. Surgical resection and ablation therapy have limited …