Copper acquisition and detoxification machineries are conserved in dimorphic fungi

D Moraes, JGC Rodrigues, MG Silva, LW Soares… - Fungal Biology …, 2023 - Elsevier
The survival of pathogenic fungi in the host after adhesion and invasion depends on their
ability to obtain nutrients, including the transition metal copper, which performs several …

A novel Zn2-Cys6 transcription factor clcA contributes to copper homeostasis in Aspergillus fumigatus

Y Kusuya, C Bian, D Hagiwara, S Ban, H Takahashi - Current Genetics, 2022 - Springer
The filamentous fungus Aspergillus fumigatus is the most important pathogenic fungus
among Aspergillus species associated with aspergillosis. A. fumigatus is exposed to diverse …

FfCOX17 is Involved in Fumonisins Production, Growth, Asexual Reproduction, and Fungicide Sensitivity in Fusarium fujikuroi

X Mao, Z Wu, F Chen, M Zhou, Y Hou - Toxins, 2022 - mdpi.com
Fusarium fujikuroi, a causal agent of Rice Bakanae Disease, produces secondary
metabolites such as gibberellin, pigments bikaverin, and mycotoxins fumonisins. Fumonisins …

Evolution of the pathogenic mold Aspergillus fumigatus on high copper levels identifies novel resistance genes

M Handelman, Z Meir, Y Shadkchan, A Abo Kandil… - mSphere, 2024 - Am Soc Microbiol
Aspergillus fumigatus is the leading cause of severe mold infections in
immunocompromised patients. This common fungus possesses innate attributes that allow it …

Ambient Availability of Amino Acids, Proteins, and Iron Impacts Copper Resistance of Aspergillus fumigatus

A Yap, H Talasz, H Lindner, R Würzner… - Frontiers in Cellular and …, 2022 - frontiersin.org
The transition metals iron and copper are required by virtually all organisms but are toxic in
excess. Acquisition of both metals and resistance to copper excess have previously been …

Identification and Analysis of Fungal-Specific Regions in the Aspergillus fumigatus Cu Exporter CrpA That Are Essential for Cu Resistance but Not for Virulence

H Werner, A Abou Kandil, Z Meir, Y Malis… - International Journal of …, 2023 - mdpi.com
The opportunistic fungus Aspergillus fumigatus is the primary invasive mold pathogen in
humans, and is responsible for an estimated 200,000 yearly deaths worldwide. Most …

Molecular Interactions of the Copper Chaperone Atx1 of Paracoccidioides brasiliensis with Fungal Proteins Suggest a Crosstalk between Iron and Copper …

MAB de Carvalho Júnior, LOHS Silva, LL Pigosso… - Microorganisms, 2023 - mdpi.com
Paracoccidioides spp. are endemic fungi from Latin America that cause
Paracoccidioidomycosis, a systemic disease. These fungi present systems for high-affinity …