Breast cancer (BC) is known to be a highly heterogeneous disease that is clinically
subdivided into four primary molecular subtypes, each having distinct morphology and …

Neoantigens generated by somatic nonsynonymous mutations are key targets of tumor-
specific T cells, but only a small number of mutations predicted to be immunogenic are …

The mouse 4T1 mammary carcinoma is a BALB/c-derived tumor that spontaneously
metastasizes and induces immune suppression. Although> 95% of wild type BALB/c mice …

There are still some gaps in existing knowledge in the field of cancer nanotheranostics, eg.,
the efficiency of nanoparticle-loaded cells for targeted delivery. In the current study, gold …

The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic
and invasive and, unlike most tumor models, can spontaneously metastasize from the …

Purpose: Ionizing radiation therapy (RT) is an important component in the management of
breast cancer. Although the primary tumor can be successfully treated by surgery and RT …

Effective cell-mediated antitumor immunity requires the activation of tumor-reactive T cells
and the trafficking of activated T cells to tumor sites. These processes involve the …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …

Posttranslational modification of chromatin by histone methylation has wide-ranging effects
on nuclear function, including transcriptional regulation, maintenance of genome integrity …

We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate
immune surveillance against tumor development. In this study, we describe the use of TRAIL …