Objectives Hypertension is one of the most important risk factors for cardio-cerebral vascular
diseases, which brings a heavy economic burden to society and becomes a major public …

CC motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an
integral chemotactic factor which recruits macrophages for the immune response. Together …

Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at
20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality …

Pregnancy implies delicate immunological balance between two individuals, with constant
changes and adaptions in response to maternal capacity and fetal demands. We performed …

The maternal immune response is essential for successful pregnancy, promoting immune
tolerance to the fetus while maintaining innate and adaptive immunity. Uncontrolled …

Problem Inappropriate activation of the immune system, particularly the imbalance of T
helper type 17 (Th17)/regulatory T (Treg) cells is thought to play considerable roles in …

Preeclampsia (PE) is a unique pathophysiologic situation that physiologic interests of
mother, fetus, and placenta diverge. PE is related to the increased circulating antiangiogenic …

Superimposed preeclampsia complicates about 20% of pregnancies in women with chronic
hypertension and is associated with increased maternal and perinatal morbidity compared …

Preeclampsia is one of the most severe pregnancy complications and a leading cause of
maternal death. However, early diagnosis of preeclampsia remains a clinical challenge …

Background Preeclampsia is a pregnancy-specific hypertensive disorder characterized by
impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC) …