Objectives: Hypertension is the leading risk factor for cardiovascular disease. While
treatment of high blood pressure is essential in cardiovascular disease prevention or …

1. Intravenous ACE inhibitor therapy is of increasing importance in the treatment of patients
with unstable heart failure after myocardial infarction. Available pharmacokinetic and …

The effect of an intravenous infusion of captopril was evaluated in 13 patients suffering from
New York Heart Association class III heart failure. Various hemodynamic and neurohumoral …

Normal individuals have time-dependent variations in cardiovascular function, most of which
are circadian (once daily). They include changes in heart rate, systemic arterial blood …

Objective To assess the pharmacodynamic activity and safety of rising single and multiple
doses of intravenous quinaprilat compared with placebo in patients with New York Heart …

The renin-angiotensin system (RAS) has both localized and systemic effects in the
pathophysiology of heart failure. These may lead to structural changes in the heart and …

A range of studies are described examining the responses to blockade of the renin
angiotensin system with angiotensin converting enzyme inhibition in patients with heart …