The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment

L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary liver
diseases worldwide and can develop into various conditions, ranging from simple steatosis …

Inflammasome-mediated inflammation in liver ischemia-reperfusion injury

MB Jiménez-Castro, ME Cornide-Petronio… - Cells, 2019 - mdpi.com
Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

Aging aggravated liver ischemia and reperfusion injury by promoting STING‐mediated NLRP3 activation in macrophages

W Zhong, Z Rao, J Rao, G Han, P Wang, T Jiang… - Aging cell, 2020 - Wiley Online Library
Although aggravated liver injury has been reported in aged livers post‐ischemia and
reperfusion (IR), the underlying mechanism of innate immune activation of aged …

Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways

B Rostom, R Karaky, I Kassab, MSI Veitía - European Journal of …, 2022 - Elsevier
Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …

Dexmedetomidine alleviates hepatic ischaemia‐reperfusion injury via the PI3K/AKT/Nrf2‐NLRP3 pathway

Y Wu, G Qiu, H Zhang, L Zhu, G Cheng… - Journal of cellular …, 2021 - Wiley Online Library
Hepatic ischaemia‐reperfusion (I/R) injury constitutes a tough difficulty in liver surgery.
Dexmedetomidine (Dex) plays a protective role in I/R injury. This study investigated …

The role of NLRP3 inflammasome-mediated pyroptosis in ischemic stroke and the intervention of traditional Chinese medicine

JX Long, MZ Tian, XY Chen, HH Yu, H Ding… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is the second leading cause of death and disability in the world.
Pyroptosis, a form of programmed cell death initiated by caspases, participates in the …

The role of NF-κB triggered inflammation in cerebral ischemia

T Jover-Mengual, JY Hwang, HR Byun… - Frontiers in cellular …, 2021 - frontiersin.org
Cerebral ischemia is a devastating disease that affects many people worldwide every year.
The neurodegenerative damage as a consequence of oxygen and energy deprivation, to …

Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-κB/NLRP3 pathway-mediated inflammation and apoptosis

X Xie, F Wang, X Li - Journal of Receptors and Signal Transduction, 2022 - Taylor & Francis
Purpose Many proteins in tripartite motif (TRIM) family have been reported to play an
important role in cerebral ischemia/reperfusion (I/R) injury. This study was designed to …

Mangiferin for the Management of Liver Diseases: A Review

L Li, Y Dong, X Liu, M Wang - Foods, 2023 - mdpi.com
The liver is a digestive and metabolic organ, and several factors can induce liver damage,
which is a severe threat to human health. As a natural polyphenolic compound, mangiferin …

Transcriptional changes in orthotopic liver transplantation and ischemia/reperfusion injury

Y Ma, C Wang, G Xu, X Yu, Z Fang, J Wang, M Li… - Transplant …, 2022 - Elsevier
Background There are few effective targeting strategies to reduce liver ischemia-reperfusion
injury (IRI), which is one of the reasons for the poor prognosis of liver transplant recipients …