The ischemic stroke is a major global health concern, with high mortality and disability rates.
Unfortunately, there is a dearth of effective clinical interventions for managing poststroke …

Abstract Chemogenetic approaches using Designer Receptors Exclusively Activated by
Designer Drugs (DREADD, a family of engineered GPCRs) were recently employed in …

Cerebrovascular diseases (CVDs) are a major threat to global health. Elucidation of the
molecular mechanisms underlying the pathology of CVDs is critical for the development of …

Immunosenescence refers to the multifaceted and profound alterations in the immune
system brought about by aging, exerting complex influences on the pathophysiological …

The development of the concept of the neurovascu-lar unit (NVU) in the early 2000s has
been useful in organizing studies aimed at understanding and integrating interactions …

The annual number of strokes continues to increase particularly among people younger
than 70 years, making it a leading cause of disability. 1, 2 Ischemia from occlusion or severe …

Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating
cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and …

Aims Peripheral immune cells infiltrating into the brain trigger neuroinflammation after an
ischemic stroke. Partial immune cells reprogram their function for neural repair. Which …

Restoration of blood-brain barrier (BBB) dysfunction, which drives worse outcomes of
ischemic stroke, is a potential target for therapeutic opportunities, whereas a sealed BBB …

Ischemic stroke is an acute local decrease in cerebral blood flow due to a thrombus or
embolus. Of particular importance is the study of the genetic systems that determine the …