The role of microRNAs in the pathophysiology of human central nervous system: a focus on neurodegenerative diseases
Abstract microRNAs (miRNAs) are suggested to play substantial roles in regulating the
development and various physiologic functions of the central nervous system (CNS). These …
development and various physiologic functions of the central nervous system (CNS). These …
Biomarkers for Alzheimer's disease early diagnosis
E Ausó, V Gómez-Vicente, G Esquiva - Journal of Personalized Medicine, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, affecting the central
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …
The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives
H Walgrave, L Zhou, B De Strooper, E Salta - Molecular …, 2021 - Springer
Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with loss of cognitive,
executive, and other mental functions, and is the most common form of age-related …
executive, and other mental functions, and is the most common form of age-related …
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease
F Zhang, R Zhong, C Cheng, S Li, W Le - Acta Pharmacologica Sinica, 2021 - nature.com
As the population ages, Alzheimer's disease (AD), the most common neurodegenerative
disease in elderly people, will impose social and economic burdens to the world. Currently …
disease in elderly people, will impose social and economic burdens to the world. Currently …
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease
K Zheng, F Hu, Y Zhou, J Zhang, J Zheng, C Lai… - Nature …, 2021 - nature.com
Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of
Alzheimer's disease (AD), but most abnormally expressed miRNAs found in AD are not …
Alzheimer's disease (AD), but most abnormally expressed miRNAs found in AD are not …
Exosome based miRNA delivery strategy for disease treatment
Abstract miRNA, which is a common non-coding RNA, can target various mRNAs to regulate
their physiological activities. Therefore, miRNAs play an important role in various …
their physiological activities. Therefore, miRNAs play an important role in various …
MicroRNA networks in cognition and dementia
GS Blount, L Coursey, J Kocerha - Cells, 2022 - mdpi.com
The change from viewing noncoding RNA as “junk” in the genome to seeing it as a critical
epigenetic regulator in almost every human condition or disease has forced a paradigm shift …
epigenetic regulator in almost every human condition or disease has forced a paradigm shift …
Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease
Rivastigmine (or Exelon) is a cholinesterase inhibitor, currently used as a symptomatic
treatment for mild-to-moderate Alzheimer's disease (AD). Amyloid-β peptide (Aβ) generated …
treatment for mild-to-moderate Alzheimer's disease (AD). Amyloid-β peptide (Aβ) generated …
Potential implications of miRNAs in the pathogenesis, diagnosis, and therapeutics of Alzheimer's disease
L Wang, X Shui, Y Diao, D Chen, Y Zhou… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex multifactorial disorder that poses a substantial
burden on patients, caregivers, and society. Considering the increased aging population …
burden on patients, caregivers, and society. Considering the increased aging population …