In the last few years, there has been a wave of articles related to behavioral addictions;
some of them have a focus on online pornography addiction. However, despite all efforts, we …

Opioid use disorder is classified as a chronic recurrent disease of the central nervous
system (CNS) which leads to personality disorders, co-morbidities and premature death. It …

Traditional factors that once explained men's sexual difficulties appear insufficient to account
for the sharp rise in erectile dysfunction, delayed ejaculation, decreased sexual satisfaction …

Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …

Addictive drugs increase ventral tegmental area (VTA) dopamine (DA) neuron activity
through distinct cellular mechanisms, one of which involves disinhibition of DA neurons by …

Drug-evoked synaptic plasticity is observed at many synapses and may underlie
behavioural adaptations in addiction. Mechanistic investigations start with the identification …

Cigarette smoking is often initiated during adolescence and an earlier age of onset is
associated with worse health outcomes later in life. Paradoxically, the transition towards …

Substance use and abuse begin during adolescence. Male and female adolescent humans
initiate use at comparable rates, but males increase use faster. In adulthood, more men than …

This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens
(NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental …

Pavlovian cues [conditioned stimulus (CS+)] often trigger intense motivation to pursue and
consume related reward [unconditioned stimulus (UCS)]. But cues do not always trigger the …