Modern societies are experiencing an increasing trend of reduced sleep duration, with
nocturnal sleeping time below the recommended ranges for health. Epidemiological and …

Background The implication of gut microbiota in the control of brain functions in health and
disease is a novel, currently emerging concept. Accumulating data suggest that the gut …

Background Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with
COVID-19 and neurological involvement from large-scale multicenter studies are missing so …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and
transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic. Although COVID-19 …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

Impairment of the blood–brain barrier (BBB) integrity is implicated in the numerous
neurological disorders associated with neuroinflammation, neurodegeneration and aging. It …

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical manifestations of COVID-19 …