Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17
million people die worldwide from CVD per year. There is considerable evidence suggesting …

Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

Pregnancy outcomes in patients with pulmonary hypertension remain poor despite
advanced therapies. Although consensus guidelines recommend against pregnancy in …

Sex has a profound impact on myocardial remodeling, which is defined as the molecular
and cellular events after an injury to the myocardium (ie, necrosis, pressure overload …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Cardiovascular disease (CVD) is one of the leading causes of mortality in developed
countries. The incidence of CVD is sexually dimorphic, and research has focused on the …

Rationale: Although premenopausal females have a lower risk for cardiovascular disease,
the mechanism (s) are poorly understood. Objective: We tested the hypothesis that …

Atherosclerosis is the leading cause of death in the United States and worldwide, yet more
men die from atherosclerosis than women, and at a younger age. Women, on the other …