Nano-scale delivery systems for siRNA delivery in cancer therapy: New era of gene therapy empowered by nanotechnology

N Ebrahimi, MS Manavi, A Nazari, A Momayezi… - Environmental …, 2023 - Elsevier
RNA interference (RNAi) is a unique treatment approach used to decrease a disease's
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …

Wnt/β-catenin signaling pathway in the development and progression of colorectal cancer

K He, WJ Gan - Cancer Management and Research, 2023 - Taylor & Francis
The Wnt/β-catenin signaling pathway is a growth control pathway involved in various
biological processes as well as the development and progression of cancer. Colorectal …

Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer

Q Sun, Q Tao, T Ming, S Tang, H Zhao, M Liu, H Yang… - Phytomedicine, 2023 - Elsevier
Background Colorectal cancer (CRC) is a malignant affliction that burdens people globally.
Overactivated Hedgehog signal is highly implicated in CRC pathogenesis. Phytochemical …

Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics

S Tang, M Wang, Y Peng, Y Liang, J Lei… - Frontiers in …, 2024 - frontiersin.org
Armeniacae semen amarum—seeds of Prunus armeniaca L.(Rosaceae)(ASA), also known
as Kuxingren in Chinese, is a traditional Chinese herbal drug commonly used for lung …

Ursolic acid's alluring journey: one triterpenoid vs. cancer hallmarks

Y Limami, A Pinon, H Wahnou, M Oudghiri, B Liagre… - Molecules, 2023 - mdpi.com
Cancer is a multifactorial disease characterized by various hallmarks, including uncontrolled
cell growth, evasion of apoptosis, sustained angiogenesis, tissue invasion, and metastasis …

Oncolytic viruses improve cancer immunotherapy by reprogramming solid tumor microenvironment

L Zhang, SA Pakmehr, R Shahhosseini, M Hariri… - Medical Oncology, 2023 - Springer
Immunotherapies using immune checkpoint inhibitors (ICIs) and chimeric antigen receptor
(CAR) T-cell therapy have achieved successful results against several types of human …

Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation

S Tang, Y Liang, M Wang, J Lei, Y Peng, Q Tao… - Frontiers in …, 2023 - frontiersin.org
Acute lung injury (ALI) is a common condition, particularly in the COVID-19 pandemic, which
is distinguished by sudden onset of respiratory insufficiency with tachypnea, oxygen …

Fabrication of targeted and pH responsive lysozyme-hyaluronan nanoparticles for 5-fluorouracil and curcumin co-delivery in colorectal cancer therapy

M Li, Y Liu, Y Liu, J Lin, L Ding, S Wu, J Gong - International Journal of …, 2024 - Elsevier
Green nanotechnology is considered a promising method to construct functional materials
with significant anticancer activity, while overcoming the shortcomings of traditional …

The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications

FA Khan, N Fang, W Zhang, S Ji - Cell Death & Disease, 2024 - nature.com
RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as
mRNAs) post-transcriptionally through interactions with unique binding sites in the 3 …

Ursolic acid ameliorates traumatic brain injury in mice by regulating microRNA-141-mediated PDCD4/PI3K/AKT signaling pathway

H Zhang, Z Xing, J Zheng, J Shi, C Cui - International …, 2023 - Elsevier
Background Neuronal apoptosis and inflammation are the key pathogenic features of
secondary brain injury, which results in the neurological impairment that traumatic brain …