In addition to protective “immune response”, sepsis is characterized by destructive
“endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction …

Recombinant adeno-associated viruses (AAVs) have emerged as promising gene delivery
vehicles resulting in three US Food and Drug Administration (FDA) and one European …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Spinal muscular atrophy is treated with onasemnogene abeparvovec, which replaces the
missing survival motor neuron 1 gene via an adeno-associated virus vector. As of July 1 …

Atypical hemolytic uremic syndrome (aHUS) is a rare but severe disorder that frequently has
a genetic component and results from the overactivation of the alternative complement …

Background Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus
(SLE) that affects approximately 40% of patients. Pathogenic immune complexes that are …

Gastrointestinal complications are common after renal transplantation, and they have a wide
clinical spectrum, varying from diarrhoea to post-transplant inflammatory bowel disease …

Introduction Eculizumab has transformed outcomes for patients with atypical hemolytic
uremic syndrome (aHUS). Its efficacy and safety profile was well characterized in the clinical …

The complement system is a major effector of humoral immunity and natural immunity. The
complement system has three independent pathways of complement activation: a classical …

Glomerulonephritis (GN) refers to a group of renal diseases affecting the glomeruli due to
the damage mediated by immunological mechanisms. A large proportion of the disease …