The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and …

The mechanisms involved in plasticity in the nervous system are thought to support
cognition, and some of these processes are affected during normal ageing. Notably …

Converging data from rodents and humans have demonstrated an age-related decline in
pattern separation abilities (the ability to discriminate among similar experiences). Several …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

Normal aging is often accompanied by impairments in forming new memories, and studies
of aging rodents have revealed structural and functional changes to the hippocampus that …

Since the brain was found to be somehow flexible, plastic, researchers worldwide have
been trying to comprehend its fundamentals to better understand the brain itself, make …

The strength and efficiency of synaptic connections are affected by the environment or the
experience of the individual. This property, called synaptic plasticity, is directly related to …

Excitatory synaptic transmission is altered during aging in hippocampal granule cells, and in
CA3 and CA1 pyramidal cells. These functional changes contribute to age-associated …

For many years part of the limbic system, the hippocampus, has been associated with
memory. The discovery of cooperativity in the nerve fibres of this part of the brain, where …