Experimental animal models for rheumatoid arthritis

N Choudhary, LK Bhatt… - Immunopharmacology …, 2018 - Taylor & Francis
Rheumatoid Arthritis (RA) is an autoimmune systemic disorder of unknown etiology and is
characterized by chronic inflammation and synovial infiltration of immune cells. RA is …

Lysoglycerophospholipids in chronic inflammatory disorders: the PLA2/LPC and ATX/LPA axes

I Sevastou, E Kaffe, MA Mouratis, V Aidinis - Biochimica et Biophysica Acta …, 2013 - Elsevier
Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB-and PI3-kinase/Akt-dependent pathways

SY Hwang, JY Kim, KW Kim, MK Park, Y Moon… - Arthritis Res Ther, 2004 - Springer
Recent studies of the pathogenesis of rheumatoid arthritis (RA) have revealed that both
synovial fibroblasts and T cells participate in the perpetuation of joint inflammation as …

[PDF][PDF] Evaluation of therapeutic targets in animal models of arthritis

L Bevaart, MJ Vervoordeldonk, PP Tak - Arthritis Rheum, 2010 - academia.edu
Rheumatoid arthritis (RA) is a chronic, systemic, immune-mediated inflammatory disease
associated with decreased life expectancy and quality of life. RA is characterized by chronic …

Cellular mechanisms of TNF function in models of inflammation and autoimmunity

M Apostolaki, M Armaka, P Victoratos, G Kollias - TNF Pathophysiology, 2010 - karger.com
The TNF/TNF receptor (TNFR) system has a prominent role in the pathogenesis of chronic
inflammatory and autoimmune disorders. Extensive research in animal models with …

Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints

N Komatsu, H Takayanagi - Frontiers in immunology, 2012 - frontiersin.org
Rheumatoid arthritis (RA) is an immune-mediated disease of the joints that is characterized
by chronic inflammation and synovial hyperplasia that eventually lead to cartilage and bone …

Autoimmune arthritis: the interface between the immune system and joints

N Komatsu, H Takayanagi - Advances in immunology, 2012 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation
and synovial hyperplasia in the joints that ultimately lead to cartilage and bone destruction …

Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level

E Jones, SM Churchman, A English… - Annals of the …, 2010 - ard.bmj.com
Objective: Achieving joint regeneration in rheumatoid arthritis (RA) represents a future
challenge. Autologous synovial mesenchymal stem cells (MSCs) could be therapeutically …

IL‐22 in tissue‐protective therapy

H Mühl, P Scheiermann, M Bachmann… - British Journal of …, 2013 - Wiley Online Library
IL‐22, a member of the IL‐10 cytokine family, has recently gained significant attention as a
protective agent in murine models of diseases driven by epithelial injury. Like its …

Th17 in animal models of rheumatoid arthritis

M Hashimoto - Journal of clinical medicine, 2017 - mdpi.com
IL-17-secreting helper CD4 T cells (Th17 cells) constitute a newly identified subset of helper
CD4 T cells that play a key role in the development of rheumatoid arthritis (RA) in its animal …