Introduction: Due to the increase in knowledge about cancer pathways, there is a growing
interest in finding novel potential drugs. Quinazoline is one of the most widespread scaffolds …

Ductal pancreatic adenocarcinoma is associated with a very poor prognosis and most
patients are given palliative care. Chemotherapy in the form of gemcitabine has been found …

Resistance to pharmacologic agents used in chemotherapy is common in most human
carcinomas, including pancreatic ductal adenocarcinoma (PDA), which is resistant to almost …

Purpose Differences in cellular levels of histone modifications have predicted clinical
outcome in certain cancers. Here, we studied the prognostic and predictive value of three …

Narciclasine (1) is a plant growth regulator that has been previously demonstrated to be
proapoptotic to cancer cells at high concentrations (≥ 1 μM). Data generated in the present …

The mutant p53Y220C (mutp53Y220C) is frequently observed in numerous tumors,
including pancreatic cancer. The mutation creates a crevice in the DNA binding core domain …

Amonafide (1), a naphthalimide which binds to DNA by intercalation and poisons
topoisomerase IIα, has demonstrated activity in phase II breast cancer trials, but has failed …

Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat
gastrointestinal and other cancers. The 5-fluorouracil metabolite, fluoro-deoxyuridine …

The progression of pancreatic cancer is dependent on local tumor growth, angiogenesis,
and metastasis. EFEMP1, a recently discovered member of the fibulin family, was …

Pancreatic carcinoma is a gastrointestinal malignancy with poor prognosis. Treatment with
gemcitabine, the most potent chemotherapeutic against this cancer up to date, is not …