Background Glycyrrhizin (GL) is a major active constituent of licorice root (Glycyrrhiza
glabra) that is considered one of the oldest and most frequently employed botanicals in …

Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of
the long-term administration of BPs. The development of BRONJ is associated with the cell …

Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder,
characterized by severe organ complication. Sickle bone disease (SBD) affects a large part …

Materials and Methods: Forty SD rats were randomly divided into sham group, HIRI group,
GL 100 mg/kg group, and GL 200 mg/kg group. The pathological alterations of liver tissue in …

Background/Aims: Mast cells are sparsely distributed in the kidneys under normal
conditions; however, the number of mast cells increases dramatically during renal …

The radiation protection strategy with chemical agents has long been based on an
antioxidative approach consisting in reducing the number of radical oxygen and nitrogen …

OBJECTIVE: Thymoquinone (TQ) is an antioxidant and anti-apoptotic substance found in the
Nigella sativa plant. Alpha-tocopherol (alpha-TP) is a potent antioxidant. We aimed to …

OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been
reported to exhibit a protective effect against cancers and prevent bone fractures. It also …

Introduction This study aimed to investigate the renal safety of Zoledronic Acid (ZOL) in
patients with osteoporosis (OP). Methods A total of 1379 patients (baseline estimated …

Background Nitrogen-containing bisphosphonates (BIS) are potent therapeutics in
osteoporosis, but their use may result in osteonecrotic side-effects in the maxillofacial …