Abstract In 1927, Arthur C. Alport first published his description of a triad of symptoms in a
family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease
characterized by destabilization of podocyte foot processes. We report that transgenic …

The balance between synthesis and degradation is crucial to maintain cellular homeostasis
and different mechanisms are known to keep this balance. In this review, we will provide a …

Biomarkers are measurable changes associated with the disease. Urine can reflect the
changes of the body while blood is under control of the homeostatic mechanisms; thus, urine …

Genetically modified immune responses to infections and self-antigens initiate most forms of
GN by generating pathogen-and danger-associated molecular patterns that stimulate Toll …

MicroRNAs (miRNAs) are essential for podocyte homeostasis, and the miR-30 family may
be responsible for this action. However, the exact roles and clinical relevance of miR-30s …

Podocytes are highly specialized epithelial cells with complex actin cytoskeletal architecture
crucial for maintenance of the glomerular filtration barrier. The mammalian Rho GTPases …

Idiopathic nephrotic syndrome (INS) describes a group of pathologies of the renal
glomerulus that result in the classic triad of heavy proteinuria, oedema and …

Epithelial–mesenchymal transition (EMT) is a tightly regulated process by which epithelial
cells lose their hallmark epithelial characteristics and gain the features of mesenchymal …