CRISPR and iPSCs: recent developments and future perspectives in neurodegenerative disease modelling, research, and therapeutics
T Sen, RP Thummer - Neurotoxicity Research, 2022 - Springer
Neurodegenerative diseases are prominent causes of pain, suffering, and death worldwide.
Traditional approaches modelling neurodegenerative diseases are deficient, and therefore …
Traditional approaches modelling neurodegenerative diseases are deficient, and therefore …
Cell reprogramming therapy for Parkinson's disease
W Dong, S Liu, S Li, Z Wang - Neural Regeneration Research, 2024 - journals.lww.com
Parkinson's disease is typically characterized by the progressive loss of dopaminergic
neurons in the substantia nigra pars compacta. Many studies have been performed based …
neurons in the substantia nigra pars compacta. Many studies have been performed based …
Reprogramming and multi-lineage transdifferentiation attenuate the tumorigenicity of colorectal cancer cells
T Guo, J Wang, M Pang, W Liu, X Zhang, A Fan… - Journal of Biological …, 2024 - ASBMB
Significant advances have been made in reprogramming various somatic cells into induced
pluripotent stem cells (iPSCs) and in multi-lineage differentiation (transdifferentiation) into …
pluripotent stem cells (iPSCs) and in multi-lineage differentiation (transdifferentiation) into …
Advances in RNA Viral Vector Technology to Reprogram Somatic Cells: The Paramyxovirus Wave
B Sharp, R Rallabandi, P Devaux - Molecular Diagnosis & Therapy, 2022 - Springer
Ethical issues are a significant barrier to the use of embryonic stem cells in patients due to
their origin: human embryos. To further the development of stem cells in a patient …
their origin: human embryos. To further the development of stem cells in a patient …
细胞重编程治疗帕金森病
W Dong, S Liu, S Li, Z Wang - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
由于帕金森病的典型病理改变是黑质致密部中多巴胺能神经元的退行性变,
许多研究都是基于补充丢失的多巴胺能神经元来治疗帕金森病. 针对细胞替代治疗的策略最初 …
许多研究都是基于补充丢失的多巴胺能神经元来治疗帕金森病. 针对细胞替代治疗的策略最初 …
LMCD1 facilitates the induction of pluripotency via cell proliferation, metabolism, and epithelial‐mesenchymal transition
Somatic cell reprogramming was achieved by lentivirus mediated overexpression of four
transcription factors called OSKM: OCT3/4, SOX2, KLF4, and c‐MYC but it was not very …
transcription factors called OSKM: OCT3/4, SOX2, KLF4, and c‐MYC but it was not very …
An Insight into the Role of GLIS1 in Embryonic Development, iPSC Generation, and Cancer
The curiosity to discover transcription factors to reprogram somatic cells to induced
pluripotent stem cells (iPSCs) resulted in the identification of a reprogramming factor, Gli …
pluripotent stem cells (iPSCs) resulted in the identification of a reprogramming factor, Gli …