The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased
risk of developing several malignancies. The biological and pathogenic importance of Hh …

Hedgehog signaling is essential for tissue development and stemness, and its deregulation
has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result …

Degrons are the elements that are used by E3 ubiquitin ligases to target proteins for
degradation. Most degrons are short linear motifs embedded within the sequences of …

The epithelial–mesenchymal transition (EMT), a prerequisite for cancer progression and
metastasis formation, is regulated not only at the transcriptional but also at the post …

Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer
therapy because its aberrant activation is implicated in several cancers. Major progress has …

The Hippo tumor suppressor pathway, originally defined in fruit flies, regulates cellular
proliferation and survival and exerts profound effects on normal mammalian cell fate and …

Hedgehog (Hh) signaling is evolutionarily conserved and plays an instructional role in
embryonic morphogenesis, organogenesis in various animals, and the central nervous …

Prostate cancer is among the most prevalent life-threatening cancers diagnosed in the male
population today. Various methods have been exploited in an attempt to treat this disease …