It is well known that female reproduction ability decreases during the forth decade of life due
to age-related changes in oocyte quality and quantity; although the number of women trying …

Zinc is a critical component in a number of conserved processes that regulate female germ
cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular …

Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for
maintenance of the species. However, the developmental trajectories and heterogeneity of …

Histone modifications are fundamental epigenetic regulators that control many crucial
cellular processes. However, whether these marks can be passed on from mammalian …

Polycomb group proteins and the related histone modification H3K27me3 can maintain the
silencing of key developmental regulators and provide cellular memory. However, how such …

Objective To characterize well-represented microRNAs in human follicular fluid (FF) and to
ascertain whether they are cargo of FF exosomes and whether they are involved in the …

Erasure and subsequent reinstatement of DNA methylation in the germline, especially at
imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms …

ABSTRACT Children conceived by Assisted Reproductive Technologies (ART) are at
moderately increased risk for a number of undesirable outcomes, including low birth weight …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …

Mammalian experiments provide clear evidence of male line transgenerational effects on
health and development from paternal or ancestral early-life exposures such as diet or …