Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

All animal subcellular membranes require cholesterol, which influences membrane fluidity
and permeability, fission and fusion processes, and membrane protein function. The …

We test whether the dysfunction with age of carnitine acetyltransferase (CAT), a key
mitochondrial enzyme for fuel utilization, is due to decreased binding affinity for substrate …

Ischemia-reperfusion injury to cardiac myocytes involves membrane damage mediated by
oxygen free radicals. Lipid peroxidation is considered a major mechanism of oxygen free …

Mitochondria play an essential role in the energy metabolism of the heart. Many of the
essential functions are associated with mitochondrial membranes and oxidative …

Mitochondria decay with age due to the oxidation of lipids, proteins, RNA, and DNA. Some of
this decay can be reversed in aged animals by feeding them the mitochondrial metabolites …

Mitochondria require cholesterol for biogenesis and membrane maintenance, and for the
synthesis of steroids, oxysterols and hepatic bile acids. Multiple pathways mediate the …

Mitochondrial decay has been postulated to be a significant underlying part of the aging
process. Decline in mitochondrial function may lead to cellular energy deficits, especially in …

Background: Results of studies in experimental animals have shown that, with age,
myocardial fatty acid metabolism decreases, and glucose metabolism increases. Whether …

Oxidative mitochondrial decay is a major contributor to aging. Some of this decay can be
reversed in old rats by feeding them normal mitochondrial metabolites, acetylcarnitine (ALC) …