The tumor microenvironment (TME) is shaped by dynamic metabolic and immune
interactions between precancerous and cancerous tumor cells and stromal cells like …

The evasion from controlled cell death induction has been considered as one of the
hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in …

Carcinoembryonic antigen (CEA), a glycosylated protein of MW 180 kDa, is overexpressed
in a wide range of human carcinomas, including colorectal, gastric, pancreatic, non-small …

Breast cancer has a high incidence and mortality rate worldwide. Several viral vectors
including lentiviral, adenoviral and adeno-associated viral vectors have been used in gene …

Survivin is overexpressed in major types of cancer and is considered an ideal “universal”
tumor-associated antigen that can be targeted by immunotherapeutic vaccines. However, its …

Concurrent with the US FDA's approval of the first therapeutic cancer vaccine, and
supported by mounting clinical evidence indicating that targeting carcinoembryonic antigen …

LIGHT, a TNF superfamily member (TNFSF14), is a type II transmembrane protein
expressed on activated T cells and immature dendritic cells (DCs). However, the expression …

Стандартные методы терапии опухолевых заболеваний обладают рядом недостатков,
главные из которых неспецифичность и тяжелые побочные эффекты. Кроме того …

The routine methods used to treat oncological diseases have a number of drawbacks,
including non-specific action and severe side effects for patients. Furthermore, tumor …

In vitro studies have demonstrated that cancer-specific T cell cytotoxicity can be induced
both ex vivo and in vivo, but this therapeutic strategy should probably be used as an …