Beyond mechanical loading: The metabolic contribution of obesity in osteoarthritis unveils novel therapeutic targets

BH Sobieh, HO El-Mesallamy, DH Kassem - Heliyon, 2023 - cell.com
Osteoarthritis (OA) is a prevalent progressive disease that frequently coexists with obesity.
For several decades, OA was thought to be the result of ageing and mechanical stress on …

Molecular mechanisms linking osteoarthritis and Alzheimer's disease: shared pathways, mechanisms and breakthrough prospects

IO Umoh, HJ Dos Reis, ACP de Oliveira - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease mostly affecting the
elderly population. It is characterized by cognitive decline that occurs due to impaired …

Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy

J Wan, Z He, R Peng, X Wu, Z Zhu, J Cui, X Hao… - Journal of …, 2023 - Springer
Osteoarthritis (OA) is a common degenerative joint disease urgently needing effective
treatments. Bone marrow mesenchymal stromal cell-derived exosomes (Exo) are …

Corticosteroid injections for the treatment of osteoarthritis present a wide spectrum of effects ranging from detrimental to disease‐modifying: A systematic review of …

A Bensa, M Salerno, A Boffa… - Knee Surgery …, 2024 - Wiley Online Library
Purpose Aim of this systematic review of preclinical evidence was to determine the effects of
intra‐articular corticosteroid (CS) injections in joints affected by osteoarthritis (OA). Methods …

[HTML][HTML] Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of osteoarthritis

G Bordon, F Berenbaum, O Distler, P Luciani - Biomedicine & …, 2023 - Elsevier
Osteoarthritis (OA) is a widespread joint condition affecting millions globally, presenting a
growing socioeconomic burden thus making the development of more effective therapeutic …

[PDF][PDF] Болезнь-модифицирующие остеоартрит препараты (DMOADs)–новые тенденции в терапии пациентов с остеоартритом

ОА Шавловская, ОА Громова, АЮ Кочиш… - …, 2023 - core.ac.uk
РЕЗЮМЕ В обзоре рассматриваются фармакологические средства, которые могут
претендовать на статус потенциальных болезньмодифицирующих остеоартрит …

Tuning the Response of Synthetic Mechanogenetic Gene Circuits Using Mutations in TRPV4

YS Kim, N Steward, A Kim, I Fehle… - Tissue Engineering Part …, 2024 - liebertpub.com
Conventional gene therapy approaches for drug delivery generally rely on constitutive
expression of the transgene and thus lack precise control over the timing and magnitude of …

[HTML][HTML] Mesenchymal Stem Cell-Derived Exosomes as a Treatment Option for Osteoarthritis

A Vadhan, T Gupta, WL Hsu - International Journal of Molecular Sciences, 2024 - mdpi.com
Osteoarthritis (OA) is a leading cause of pain and disability worldwide in elderly people.
There is a critical need to develop novel therapeutic strategies that can effectively manage …

[HTML][HTML] Effect of Blood on Synovial Joint Tissues: Potential Role of Ferroptosis

HJ Nicholson III, N Sakhrani, J Rogot, AJ Lee… - Applied Sciences, 2024 - mdpi.com
Recurrent bleeding in the synovial joint, such as the knee, can give rise to chronic synovitis
and degenerative arthritis, which are major causes of morbidity. Whereas chronic …

Active Sensing of Knee Osteoarthritis Progression with Reinforcement Learning

K Nguyen, HH Nguyen, E Panfilov, A Tiulpin - arXiv preprint arXiv …, 2024 - arxiv.org
Osteoarthritis (OA) is the most common musculoskeletal disease, which has no cure. Knee
OA (KOA) is one of the highest causes of disability worldwide, and it costs billions of United …