Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

An organoid is a 3D organization of cells that can recapitulate some of the structure and
function of native tissue. Recent work has seen organoids gain prominence as a valuable …

In recent years, our scientific interest in spaceflight has grown exponentially and resulted in
a thriving area of research, with hundreds of astronauts spending months of their time in …

During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

The spaceflight environment, including microgravity and radiation, may have considerable
effects on the health and performance of astronauts, especially for long-duration and Martian …

Bioprinting as an extension of 3D printing offers capabilities for printing tissues and organs
for application in biomedical engineering. Conducting bioprinting in space, where the gravity …

Space travelers are exposed to microgravity (µ g), which induces enhanced bone loss
compared to the age-related bone loss on Earth. Microgravity promotes an increased bone …

Microgravity-induced bone loss results in a 1% bone mineral density loss monthly and can
be a mission critical factor in long-duration spaceflight. Biomolecular therapies with dual …

Microphysiological systems provide the opportunity to model accelerated changes at the
human tissue level in the extreme space environment. Spaceflight-induced muscle atrophy …

The molecular mechanisms of skeletal muscle adaptation to spaceflight are as yet not fully
investigated and well understood. The MUSCLE BIOPSY study analyzed pre and postflight …