Antibiotic-induced collateral damage to the microbiota and associated infections

L de Nies, CM Kobras, M Stracy - Nature Reviews Microbiology, 2023 - nature.com
Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …

Interkingdom interactions between Pseudomonas aeruginosa and Candida albicans affect clinical outcomes and antimicrobial responses

LJ Kahl, N Stremmel, MA Esparza-Mora… - Current Opinion in …, 2023 - Elsevier
Infections that involve interkingdom microbial communities, such as those between bacteria
and yeast pathogens, are difficult to treat, associated with worse patient outcomes, and may …

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance

MJ Shepherd, T Fu, NE Harrington, A Kottara… - Nature Reviews …, 2024 - nature.com
The ecological and evolutionary mechanisms of antimicrobial resistance (AMR) emergence
within patients and how these vary across bacterial infections are poorly understood …

One species, many faces: The underappreciated importance of strain diversity

J Nysten, D Sofras, P Van Dijck - PLoS Pathogens, 2024 - journals.plos.org
Over the past century, extensive efforts have been made to isolate and categorize thousands
of strains, resulting in the classification of species as a group of strains that form a coherent …

The microbiota: a crucial mediator in gut homeostasis and colonization resistance

Y Chen, L Xiao, M Zhou, H Zhang - Frontiers in Microbiology, 2024 - frontiersin.org
The gut microbiota is a complex and diverse community of microorganisms that colonizes
the human gastrointestinal tract and influences various aspects of human health. These …

Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade bacteria from the respiratory microbiome

S Lindon, S Shah, DR Gifford, C Lood… - Evolution …, 2024 - academic.oup.com
The emergence and spread of antibiotic resistance in bacterial pathogens is a global health
threat. One important unanswered question is how antibiotic resistance influences the ability …

Double-Network Hydrogel with Strengthened Mechanical Property for Controllable Release of Antibacterial Peptide

T Tan, Y Hou, Y Zhang, B Wang - Biomacromolecules, 2024 - ACS Publications
Developing double-network (DN) hydrogels with high mechanical properties and
antibacterial efficacy to combat multidrug-resistant bacterial infections and serve as scaffolds …

Epidemiology of healthcare-associated Pseudomonas aeruginosa in intensive care units: are sink drains to blame?

C Volling, L Mataseje, L Graña-Miraglia, X Hu… - Journal of Hospital …, 2024 - Elsevier
Background Pseudomonas aeruginosa (PA) is a common cause of healthcare-associated
infection (PA-HAI) in the intensive care unit (ICU). Aim To describe the epidemiology of PA …

The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection

J Vanderwoude, S Azimi, TD Read, SP Diggle - Mbio, 2024 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …

Demographic fluctuations in bloodstream Staphylococcus aureus lineages configure the mobile gene pool and antimicrobial resistance

SSR Souza, JT Smith, MM Marcovici… - npj Antimicrobials and …, 2024 - nature.com
Staphylococcus aureus in the bloodstream causes high morbidity and mortality, exacerbated
by the spread of multidrug-resistant and methicillin-resistant S. aureus (MRSA). We aimed to …